One or two postdoctoral fellows in Biophysics

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 42,000 students, 7,000 employees and a turnover of SEK 6.7 billion.

 

The Department of Cell and Molecular Biology is one of the most international, broad and distinguished bio-molecular departments in Europe, comprising six research programs with about 130 employees. This position is within the research lab of Sebastian Deindl (deindl‑lab.com).

 

Overall description Molecular machines are proteins that convert chemical energy into conformational changes to carry out work in the cell. Our group studies the structural architectures and dynamics of molecular machines with focus on nucleic-acid interacting enzymes whose aberrant function or dysregulation is often associated with severe disease states. Single-molecule imaging approaches that directly visualize molecular machines in real time give us a unique possibility to decipher their complex regulation and correlate structural dynamics with function.

 

Job assignment We use an innovative approach to characterize the dynamics and regulation of chromatin-associated protein machines. As part of a project funded by an ERC starting grant, you will develop and apply single-molecule fluorescence imaging methodologies with the ultimate goal to describe function and regulation. This assignment comprises experimental design, imaging/data acquisition and state-of-the-art data analysis. You will carry out experiments independently but also interact with other members of the team.

 

Qualifications required:

• PhD in Biophysics
• Experience with single-molecule biophysics

• Experience in the automation of experiments using LabView and MicroManager
• Good knowledge of Image processing and scripting in e.g. ImageJ
• Basic programming skills (e.g. MATLAB)
• Excellent communication skills in English

 

Qualifications desired:

• Experience with single-molecule FRET
• Experience with the assembly and purification of nucleosomes
• Proficient in standard biochemistry methods
• Proficient in molecular cloning techniques

• Molecular modeling skills

 

The application Your application must include a CV, full publication list, copies of diplomas and certificates, contact details of two references, and a personal letter including a short description of research interests. The application will be evaluated based on the following criteria: Appropriate education and work/research in related fields. Emphasis will also be placed on personal skills. The applicant should be fluent in English as the research is conducted in an international environment.

 

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

 

Pay: Individual salary

 

Starting: 1st of October 2018 or according to agreement

 

Type of employment: Temporary position for two years.

 

Working hours: 100 %

 

For further information about the position please contact
Sebastian Deindl (sebastian.deindl@icm.uu.se)

 

You are welcome to submit your application no later than 19th of August 2018, UFV-PA 2018/1543.

 

Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at ifss@uadm.uu.se.

 

We decline offers of recruitment and advertising help. We only accept the application the way described in the advertisement.

 

Placement: Department of Cell and Molecular Biology

 

Type of employment: Full time , Temporary position longer than 6 months

 

Pay: Fixed salary

 

Number of positions: 1

 

Working hours: 100%

 

Town: Uppsala

 

County: Uppsala län

 

Country: Sweden

 

Union representative: Ellena Papaioannou, Seko 018-471 3315
Suzanne Borén Andersson, TCO/ST 018-471 6251
Per Sundman, Saco-rådet 018-471 1485
Number of reference: UFV-PA 2018/1543

 

Last application date: 2018-08-19