In this Scientific Reports paper authors used quantitative and correlative analyses to assess the performance of Structured Illumination Microscopy (SIM), STimulated Emission Depletion (STED) microscopy and Single Molecule Localisation Microscopy (SMLM) the aim of establishing a rough guideline regarding the suitability for typical applications and to highlight pitfalls associated with the different techniques.
Engineers at FAU have developed a method for increasing the resolution of digital cameras by four times without having to use larger and more expensive image sensors. This is achieved by irregularly scanning the pixels and reconstructing the image afterwards. The next step involves developing a prototype that will enable more research to be carried out.
The 3D viewer in FiJi (ImageJ) will soon be optional as there is a new viewer, FPBioimage, coming that looks very promising.
With a small efforts this paper describes how you can turn your cell phone into a decent microscope. They show a resolution down to 4.38 µm – try it out!
Interesting science that could change the design of light microscopes and give new possibilites.
The Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson “for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution”.
Here is the official news that the Nobel Prize in Chemistry goes to the inventors/developers of Cryo Electron Microscopy. The Nobel Laureates are Jacques Dubochet, University of Lausanne, Switzerland, Joachim Frank, Columbia University, New York, USA and Richard Henderson, MRC Laboratory of Molecular Biology, Cambridge, UK.
It has now been shown that there is an easier and cheaper way to produce high NA lenses than by hand polishing.
Although this is not bioimaging, it is a very interesting example of what microscopes are capable of. And it has attracted a lot of attention to the field.
Check out the video on the details of the microscope and the cars:
And hear the result of the race:
Through two expansions the samples get up to 20x bigger and allow for detection of details that would correspond to STORM resolution. Quite impressive results.