Location: Montreal, Canada

Type: Postdoc

Live Cell Imaging and Quantitative Image Analysis

 

Overview:

Applications are invited for a Research Associate/Postdoctoral Fellow in the Brown lab, in collaboration with the Advanced BioImaging Facility at McGill University in Montreal, Canada. Candidates should have a Ph.D. degree in the areas of Biophysics, Cell Biology, Cancer Biology, Bioengineering or a related field with an excellent track record for innovative research.

With a strong focus on interdisciplinary work the project will involve a collaboration between the ABIF facility and labs in cancer research, bioengineering and live cell imaging. McGill is ranked among the finest research-intensive universities in the world. The trainee will have access to the Advanced BioImaging Facility, Cell Imaging and Analysis Network and extensive light microscopy workshops and courses. They will have opportunities to attend seminars from world-renowned scientists speaking in Physiology, Biochemistry, Bioengineering and the Goodman Cancer Research Centre. There will also be links to the private sector for the development of custom acquisition and analysis software tools.

 

Project Summary:

The candidate will join a multidisciplinary team to conduct experiments such as live cell imaging of cell migration, adhesion dynamics, 3D cell migration, application of fluorescence-based biosensors, development of microfluidic biological model systems and development of image analysis pipelines for quantitative image analysis. The techniques will be applied to investigate the role that the mechano-sensitive protein, lipoma preferred partner (LPP), plays in regulating breast cancer cell migration, invasion and metastasis by studying mechanisms of cell migration and invasion.

 

Education and Experience:

PhD in preferred areas including Biophysics, Cell Biology, Cancer Biology, Bioengineering, Computer Science

 

Compensation:

The initial appointment is 1-year with annual renewals for 2 additional years.

Starting salary depends on experience.

Major Duties and Responsibilities:

 

  1. Perform experiments with LPP, other signaling proteins, integrins and actin binding proteins to determine the mechanisms used by LPP in regulating breast cancer.

 

  1. Live cell imaging, 3D cultures, biosensor imaging.

 

  1. Development of software tools for adhesion analysis, cell tracking in 3D, measurement of invasion in 3D systems. Streamlining analysis on multiple large datasets.

 

  1. Oversight and mentorship of graduate students working on the project.

 

  1. Keep abreast of the literation in the area.

 

  1. Take a lead role in manuscript, fellowship and grant writing.

 

  1. Present the work at national and international meetings.

 

  1. Tissue culture, transfections, live cell imaging, basic microbiology.

 

Experience in Any of These Areas is Desired:

 

  1. Python, MatLab, Visual Basic, MetaMorph.

 

  1. Live cell imaging.

 

  1. TIRF, confocal microscopy, spinning disk microscopy. light sheet microscopy.

 

  1. Working with 3D cultures an asset.

 

  1. Ability to work independently and efficiently but also work well as a part of a team.

 

  1. Strong verbal and written communication in English.

 

 

The list of duties and responsibilities outlined above is representative and not a complete and detailed list of tasks, which may be performed by an employee whose position has been matched to this description.

 

How To Apply:

Candidates should send their curriculum vitae, a one-page statement of past and future research interests, and the names and contact information of three references to:

 

Dr. Claire Brown

Associate Professor, Physiology

McGill University

claire.brown at mcgill.ca<mailto:claire.brown@mcgill.ca>