Deadline: 2018-10-16


Type: Postdoc

Postdoctoral Researcher Position at the
Buchmann Institute for molecular life sciences,
Goethe University Frankfurt, Germany
(Postdoctoral Researcher, E 13 TV-G-U)
Host university:
With more than 46.000 students and approx. 4.600 employees the Goethe University Frankfurt is one of
the largest universities in Germany. The Goethe University is positioned among the top international
research universities, offers a wide variety of academic programmes, a diverse group of research
institutes, and a focus on interdisciplinary approaches to solving complex problems. The university
comprises 5 campuses with 16 faculties, 100 study courses and has an excellent focus on research. With
600 Germany scholarships and a total of 1,08 million euros in supporting donations, the university once
more ranked top among German universities in this category. Situated in Germany’s most cosmopolitan
and international city, the university attracts a diverse body of students and researchers from around the
world. Students at Goethe benefit from studying and living in Frankfurt, the largest financial and trading
centre in Europe—with plenty of opportunities to learn and practise speaking German.
Group description:
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that remains one of the major
burdens on our society with no available cure. AD, in combination with vascular cognitive impairment
(VCI), represents over 80% of the total dementia cases. At autopsy the overlap of the underlying
pathological hallmarks of AD (beta-amyloid (Ab) plaques and neurofibrillary tangles) and VCI (strokes,
small vessel disease and vascular dementia) is obvious, but is often unrecognized in the clinical setting.
Hence, our group is focused on the basic research of the comorbidity states of AD and VCI to investigate
underlying disease pathways as well as potential biomarker profiles. The neurovascular unit is of
particular interest to us and we aim to investigate the long-term interplay of vascular cognitive
impairments with Alzheimer’s Disease. The function of the neurovascular unit and its alteration during
disease progression is investigated using various methods including in vivo 2 Photon imaging, RNA
sequencing, primary cell culture, and molecular biology. This position, therefore, provides the
opportunity to conduct research in the field of neurovascular disorders in a vibrant and well-rounded
Institute of Cell Biology and Neuroscience
Max-von-Laue Str. 13
Neurovascular Disorders Group
Buchmann Institute for Molecular Life
Max-von-Laue-Str. 15
D-60438 Frankfurt am Main
Dr. Jasmin Hefendehl
Postdoctoral Position Goethe University, Institute of Cell Biology and Neuroscience and BMLS
The Position:
We are seeking to fill the position at the earliest possible opportunity. The position is initially limited to
August 31th, 2021, with the possibility of extension. The funded project aims to characterize and track
the functional aspects of the neurovascular unit in transgenic mouse models mimicking the comorbidity
of Alzheimer’s Disease and vascular cognitive impairments. Further analysis will include the
investigation of the amyloid clearance mechanisms from the brain parenchyma, the integrity of the BBB
as well as different aspects of cell signalling changes. Methods that are used include the use of
intracranial in vivo 2 Photon imaging, acute brain slices, primary cell culture models of the blood brain
barrier as well as immunohistochemistry and molecular biology.
General requirements:
We are seeking enthusiastic and ambitious candidates with a strong background in neurodegenerative
disorders, stroke, cellular and molecular biology. We encourage interdisciplinary work and invite
candidates with a background is physics and experience in 2-Photon imaging who show a keen interest
in the functional mechanisms of the neurovascular unit is disease states for application. Candidates are
required to have a PhD in biology or physics.
Our laboratory is part of a multidisciplinary, modern institute which is highly international, dynamic
and scientifically stimulating. Good communication skills and the ability to work in a multidisciplinary
team are required. The common language in the institute is English with applications from abroad
especially welcome. As an equal opportunity employer, applications of women are specifically
invited. In the case of equal qualifications, competence, and specific achievements, women will be
considered on preferential terms within the framework of the legal possibilities. The Goethe
University is committed to giving preference to handicapped candidates with equivalent
qualifications. The limitation of the contract is based upon the regulations of the
“Wissenschaftszeitvertragsgesetz” in conjunction with the “Hessischen Hochschulgesetz”.
Contact and Deadline:
Please send the formal application including
1) Cover letter
2) CV
3) 2 reference letters
Until October 16th, 2018 to Hefendehl(at) and bataille(at)